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DepMap
- Alternate Title(s)
- Cancer Dependency Map
- Description
The mutations that cause cancer cells to grow also confer specific vulnerabilities that normal cells lack. Some of these acquired alterations represent compelling therapeutic targets. The challenge is that, for the overwhelming majority of cancers, we do not fully understand the relationship between the genetic alterations of cancer and the dependencies they cause. To solve this problem, we are creating...
- Subject
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Big DataCancerGenomicsPrecision MedicineProteomics
- Access Rights
- Free to AllFree to all with registration
- Local Expert
- Nyasha Chambwe
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Genome-wide analysis of M1 and M2 polarized macrophages with CNI-1493 treatment
Internal Dataset- Authors
- Anthony HeskethCaroline MaloneyChristopher BehrMorris Edelman5 more author(s)...
- Description
The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecular mechanism are unknown. The effect of CNI-1493 on M2 macrophages has yet to be explored, but we hypothesize that CNI-1493 treatment will attenuate pro-tumor properties of M2 macrophages....
- Subject
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CancerGenomicsmice
- Access Rights
- Free to All
- Local Expert
- Bettie Steinberg
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Subject Domain
- Cancer 2
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- Precision Medicine 1
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